What Are the Best Cannabis Strains for Depression?

Best Cannabis Strains for Depression

Depression is one of the most prevalent mental disorders in the world. This illness makes it difficult to stay active, interested, or basically involved in life. More than 250 million people worldwide struggle with depressive disorders and this is really huge! Living a life without any desire, experiencing worthlessness, tiredness, irritability, and other typical symptoms is hard and exhausting. 

Depression is an illness that is incredibly difficult and complex. There are various ideas explaining why this is happening, with the most well-liked one blaming a neurotransmitter imbalance in the brain. Many people use marijuana for relief because it is known to affect those neurotransmitters and help with depression symptoms relief. In their reviews, users claim that there are the best weed strains for depression, like Harley Quin, Granddaddy Purple, or Pomelo strain

Let’s delve deeper into the subject to discover why cannabis is effective against depression symptoms and how to select the best strains.

Why Is Marijuana Beneficial for Depression Symptoms?

While depression is a complex mental illness, cannabis is a not less complicated plant. Research hasn’t yet fully clarified the connection between the two, and that’s important to keep in mind for those struggling with this disorder. 

Despite these complications, some people say cannabis helps them get through depression. Marijuana may give some people a higher level of mental motivation and involvement. It can increase the desire for food, social interaction, and interest in activities and creative outlets. All of it happens because of chemical compounds contained in the plant, such as cannabinoids and terpenes. 

How do cannabinoids impact the human body?

Whether or not a person uses cannabis, they all have an endocannabinoid system (ECS), endocannabinoids, and their receptors, specifically the CB-1 and CB-2 receptors. It’s possible that cannabis and depression are connected via the ECS. The endocannabinoid system is a complicated structure of naturally occurring neurotransmitters and receptors that work together to help with various human behaviors and emotions. 

In a February 2015 study on rats, researchers at the University of Buffalo’s Research Institute on Addictions discovered that endocannabinoid production was lower in states of chronic stress than in normal conditions. They concluded that the chemicals in cannabis could be useful in stabilizing endocannabinoid function and alleviating depression symptoms. However, it is important to note that this study was conducted on animals rather than humans.

THC and CBD Influence

Processed by CB-1 and CB-2 receptors, marijuana phytocannabinoid compounds tetrahydrocannabinol (THC) and cannabidiol (CBD) are known to provide positive effects on depression symptoms.


Tetrahydrocannabinol has been shown in a study by McGill University in Montreal to have antidepressant properties. Using a simulated rat model with a synthetic form of THC, researchers discovered that low dosages of THC promoted the creation of serotonin, which naturally lessens depression. They concluded that medical marijuana might lessen people’s dependence on antidepressants. However, the study also discovered that larger cannabis doses could have a negative impact and intensify depressive symptoms.

In the meantime, researchers at the University Medical Center Utrecht in the Netherlands discovered that THC could lessen a person’s negative reaction to unpleasant visuals or emotions. The results lend credence to the idea that the endocannabinoid system regulates emotional processing and that THC may be useful in treating major depression.


According to a review from 2014 that appeared in CNS & Neurological Disorders Drug Targets, CBD can affect the brain’s serotonin receptors. Given that many prescription drugs for depression, in particular selective serotonin reuptake inhibitors (SSRIs), function by controlling serotonin levels.

The Role of Terpenes

Terpenes are organic compounds that give different marijuana strains their unique scent, flavor, and medicinal properties. People with depression, depending on their needs, can reap a variety of advantages brought by terpenes. They can be used, for instance, to naturally enhance sleep, ease pain, and reduce stress. Therefore, if you’re seeking the best technique to cope with depression, don’t ignore these minor indications.

Terpenes that are helpful with depression symptoms:

1. Limonene

The terpene in marijuana that is most effective at treating depression is limonene. Regular use has been demonstrated to lessen stress and anxiety as well as depressive symptoms.

2. Pinene

Many people who are depressed or have trouble focusing find that pinene-containing weed makes them more alert and goal-focused.

3. Linalool

This terpene is widely believed to have a calming effect on the body and mind, which can lessen the symptoms of depression.

4. Caryophyllene

It functions by interacting with the CB2 cannabinoid receptor, which, according to recent studies, may help regulate mood and alleviate depression.

The Best Weed for Depression

Choosing the best strains to relieve depression symptoms is determined first and foremost by the symptoms themselves, as different strains can help with diverse conditions. For example, if you are looking for something to boost your motivation and energy, you should select Sativa-dominant cannabis. On the other hand, if you are prone to anxiety and want to relax, it is better to give a chance to indica-dominant or even hybrids. Another thing to consider when choosing marijuana strains for depression is the terpene profile. According to users’ feedback, some strains are most frequently chosen to ease depression symptoms.

  • Headband: a potent hybrid that is known for mood heightening properties.
  • Green Crack: Sativa helps consumers with motivation and energy boost.
  • Cannatonic: cannabis with an even THC ratio helps users unwind and uplift the spirit while providing body relaxation.
  • Cinex: Sativa-dominant cannabis that boosts creativity and delivers lightweight effects.
  • Harley Quin: marijuana with a balanced CBD/THC ratio stimulates clear head and focus effects.
  • Pomelo: an Indica-leaning strain that is known for euphoric cerebral effects alongside body relaxation.
  • XJ-13: Sativa-dominant weed that awakens social activity and creativity.
  • AK-47: Sativa hybrid is known for the mellow buzz and energy boost it delivers.

Final Thoughts

Cannabis users looking for a cure for depression symptoms should remember that everyone is different, and the effects of each strain may vary from person to person. There is no scientific evidence and concrete answer to the question “is weed good for depression?”. Marijuana and the symptoms of depression probably have a complicated biochemical connection. Though consumers report positive effects, much more investigation is required to determine how cannabis affects the metabolic pathways related to severe depression.

If you’re considering using cannabis to treat depression, make sure to discuss the potential of getting a medical cannabis card with a cannabis doctor if it is available in your state.

— Share —

— About the Author —

Leave a Reply

Your email address will not be published. Required fields are marked *

— Follow Us —

Up Next

Effective Treatments for COVID-19: What You Need to Know About the Drugs Paxlovid and Molnupiravir

Effective Treatments

The COVID-19 pandemic has been wreaking havoc worldwide for more than two years now, so there is an urgent need for effective treatments. The good news is that several antiviral drugs are now available that have been shown to work effectively as covid positive treatment. Two of these treatments are Paxlovid and Molnupiravir. Read on to learn more about these drugs.

Paxlovid: An Overview

It is an antiviral drug developed by Pfizer in collaboration with the biotech company Ridgeback Biotherapeutics. FDA granted the drug emergency use authorization in November 2021.

The active ingredients in it are nirmatrelvir and ritonavir. N

Up Next

Top Things You Need To Know About Home Care Services

Things You Need To Know About Home Care Services

As people age, they may need extra help to perform certain tasks. This can be for reasons such as disability or illness. This help is designed to make life easier for an older person. Sometimes you may find it difficult to manage taking care of a loved one and attend to your job.

If that is the case then you will need someone to help out. Some of the options many people choose is a nursing home for an older adult. This takes your parents away from home and may be depressing.

Something that can help here is home care in Nassau County NY according to Galaxy Home Care. You can keep your loved one at home while they can still receive all the help to perform daily tasks. There are so many benefits to choosing home care services. Here are some things you should know.

Up Next

8 Reasons Pizza Became a Cultural Phenomenon

Pizza Became a Cultural Phenomenon

You and almost everyone you know enjoys pizza at least occasionally. For some people, pizza is truly a passion. Thankfully, there's a pizza place on every corner and there are endless pizza varieties to choose from. But why do we love pizza so much? Is there something unique about this combination of flavors? Or was pizza embedded into our cultural tapestry long ago?

Countless Reasons to Enjoy Pizza

These are some of the biggest reasons why we love pizza so much.

1. Infinite possibilities.

One of the biggest advantages of pizza is that it can be prepared in nearly infinite ways. If you call up the average pizza place and ask for a list of possib

Up Next

Home Decor: 5 Tips To Keeping Your Neck Pillows Clean And New

Neck Pillows Clean

If you're anything like me, you love nothing more than a good neck pillow. They make traveling so much more comfortable and they're also great for napping. But sometimes, no matter how often you wash them, they can start to look a bit dirty and old. Here are 5 tips to keep your neck pillows looking clean and new: 1.  2. 3. 4. 5.  So next time you're feeling like your neck pillow could use a refresher, try out these tips! You'll be surprised at how well they work.

When you first get your neck pillow, make sure to wash it before using

Before we get into the comfort of neck pillows, it is important to remember to practice safe habits. When you receive your neck pillow package, don’t forget to wash the neck pillow covers before using them. This is an essential

Up Next

Moving Out, Moving On – How to Know It’s Time to Relocate

How to Know Its Time to Relocate

Moving can cause a severe blow to your mental health. In fact, 1 in 8 consider moving more stressful than jail, and 45% consider moving the most stressful life event they’ve experienced. People don’t typically move unless they need to, but when do we know when it’s the right time?

How to Know it’s Time to Move Out and Move On

It can be hard to know when it’s time to move. Yet, sometimes the signs are staring you right in the face; you just need to pay attention.

Here are 10 ways to know it’s time to move out and on.

1. You’re Stuck in a Rut

Maybe the

Up Next

How Do I Find Local Casting Calls?

How Do I Find Local Casting Calls

The entertainment industry always evolves, and people need to adapt to discover relevant jobs. New ways of finding casting calls emerge, especially with the popularity of social media and online advertising.

One of the most convenient modern ways of discovering casting opportunities is using specialized platforms. For example, you can easily see all casting calls in Virginia Beach available online. In this article, you will find some of the top ways of finding relevant casting calls.

Finding the Best Local Casting Calls

When people start looking for acting jobs and other creative options, there is a lot of confusion about where to even begin. Luckily, there are a few commo

Up Next

How to Create a Vision Board to Inspire and Motivate You

Create a Vision Board to Inspire Motivate You

Vision boards are used to manifest your goals. Whether you want to attain personal goals or business goals, vision boards can be great ways of manifesting your desires. They can also be used to inspire and motivate you.

Furthermore, vision boards are easy to create. You simply need to collect images that illustrate the things you want and then add them to a board.

Once you have completed your vision board, place it somewhere where you’ll see it each day. You’ll then be much more focused on attaining your wishes on a daily basis.

And the more focused you are and the more you envision the things you want to manifest, the easier it will be to make your wishes come true.

How to Create a Physical Vision Board