Medical & Non-Medical Ways to Handle Treatment-Resistant Depression

Handle Treatment Resistant Depression

When people suffering from depression are treated with antidepressants for more than six weeks without improvement, they may be diagnosed with treatment-resistant depression.

In such cases, they could feel better than before but still face problems such as having a hard time at work because they can’t think very well. They may also have a lot of anxiety or experience crying episodes. This clearly means that they are still suffering from depression that has only been partially cured.

Why would it not get better? 

Studies show that about 40% to 60% of cases of treatment-resistant depression can be related to bipolar disorder. That’s a pretty high percentage. So, this is something for you and your doctor to ponder over as a possible reason if you’re not getting better with antidepressants. 

The other thing your doctor should look at is possible medical issues interfering with treatment for depression. Common medical issues that can make it harder for depression to resolve completely are hypothyroidism, chronic pain, low testosterone, inflammatory illnesses, and sleep apnea. 

Medical Options

Atypical antipsychotic medications such as Risperdal and Zyprexa are some of the most studied treatment-resistant depression drugs known to be useful. A major problem with these drugs is that they are associated with excessive weight gain.

While newer ones like Abilify and Rexulti cause significantly less weight gain, they cause a condition called akathisia which is basically clinical restlessness. 

In short, most medical options have certain side effects that can be mild to extremely severe. However, newer alternatives such as spravato, are known to have relatively insignificant and temporary side effects such as dissociation, dizziness, sedation, etc. While you can take it orally, it also comes in a few other forms, such as the spravato nasal spray. 

Alternative Non-medical options.

So what if you can’t take any of these medicines because of side effects, or they aren’t working for you? You can seek the two most common non-medication options, which are electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS). 

ECT works by stimulating a seizure under general anesthesia. Although that may sound extreme, it works very well and can be useful for people who can’t take medications. However, the biggest drawback of ECT is the memory problems that come with it. Since this treatment uses anesthesia to stimulate the brain, many patients have mentioned having trouble remembering things before and after the treatment. 

Some people also say that they just don’t feel as sharp as they used to. TMS was developed to overcome this issue of memory loss. It stimulates the brain using technology that’s similar to an MRI. However, It doesn’t work as well as ECT, and you need a lot more sessions. Usually, five days a week for six weeks, making it a big-time commitment. 

The Takeaway

These alternative and additional treatments are only necessary only if the concerned person is truly treatment-resistant. For instance, if you don’t feel better despite your doctor putting you on 25 milligrams of Zoloft for two months, that’s not a failed trial of medication. The first step would be to increase to a minimum of 50, probably followed by 100 milligrams, and then make a decision depending upon the results. 

However, you may notice a tiny improvement with 50 milligrams, which may imply increasing your dose for better effectiveness. Further, if you notice problems such as reduced sex drive or insomnia, it means your body cannot handle increased doses without the side effects. This is when it’s better to look for non-medical options as discussed above or consider trying newer solutions like spravato.


— About the Author —

Leave a Reply

Your email address will not be published. Required fields are marked *

— Follow Us —

Up Next

Top Ways To Shop The Best Kratom Products For Mental Wellbeing

Best Kratom Products For Mental Wellbeing

In recent years, Kratom has emerged as a popular botanical supplement known for its potential to enhance mental well-being. With its origins in Southeast Asia, where it has been used for centuries, it is being rediscovered worldwide as a natural aid for relaxation and mood management. However, the surge in Kratom’s popularity comes with a critical responsibility: ensuring that you are sourcing and using this substance in a way that is safe and effective.

This comprehensive guide will walk you through multiple aspects of selecting the highest quality Kratom products to support your mental well-being. The importance of always checking (take the time to read the) “labels for multiple products from the manufacturer” and understanding its effects on

Up Next

Exploring Alpha Brain’s potential for refreshing aging minds

concept of brain diseases mental health alzheimers

As we grow older and  time goes on inevitably, many changes occur inside our organism, including our brain. With age, people often realize that they don’t remember certain things as they did in the past. Recalling and memorizing things is also becoming problematic. Our biological clock is ticking like a bomb, and, from a biological perspective, aging leads to changes in brain size and mental functions slowing down. Today’s world proposes different solutions for brain aging – Alpha Brain.

Unique supplement on the market

With a wide selection of brain-boosting supplements, Alpha Brain has gained a great deal of attention in the world of measures supporting and optimizing our cognitive functions. Based on the product description on many supplement store’s pages, Alpha Brain is defined as a di

Up Next

What to Expect from Generative AI In the Fintech Industry

Generative AI In the Fintech Industry

The FinTech sector is on the cusp of a revolution, spearheaded by the integration of generative AI development solutions. This transformative technology is set to redefine the landscape of financial services, offering unprecedented levels of personalization, efficiency, and security. Generative AI capability to analyze and generate data-driven insights presents a great opportunity for FinTech companies to innovate beyond traditional boundaries.

Geniusee is at the forefront of this technological advancement. It has positioned itself as a pioneer in leveraging generative AI to create sophisticated solutions tailored to the FinTech industry. With a deep underst

Up Next

Opioid Effects on Mental Health

Opioid Effects on Mental Health

The opioid epidemic emerges as a growing challenge, casting profound shadows across the mental landscapes of individuals affected.

This narrative explores an insight into the deep psychological consequences of opioid dependency, weaving through the complex relationship between substance abuse and mental health. It’s a quest for awareness, understanding, and, ultimately, a pathway to healing.

The Hidden Connection: Opioids and Mental Health

Opioids, often perceived as a remedy for physical discomfort, conceal a darker truth beneath their surface. The solace they provide is fleeting, unveiling a terrain scarred by psychological strife. The journey into dependence is a quiet one, laden with promises of relief that gradually en

Up Next

How Exercising With Your Dog Improves Your Mental Health

How Exercising With Your Dog

In the intricate landscape of mental health management, the integration of physical exercise with canine companionship emerges as a distinguished method for augmenting psychological wellness.

This scholarly discourse aims to elucidate the complex mechanisms through which engagement in physical activities with a dog serves not only as a catalyst for improved physical health but also as a significant boon to mental and emotional well-being. Through a detailed exploration of this symbiotic relationship, we uncover the nuanced benefits that canine-assisted exercise bestows upon human psychological states, thereby offering a refined understanding of its value in a comprehensive mental health strategy.

Up Next

From Therapy Room to Boardroom: 10 Steps for Psychologists Transitioning to HR

Steps for Psychologists Transitioning to HR

So, you have done your time in the therapy room, and you are now considering applying the training and knowledge you’ve acquired as a psychologist to the field of Human Resources. It is a big, brave and possibly scary step. Therefore, we reckon you might welcome a bit of guidance.

If you’re interested in pursuing a career in HR, it’s important to understand what skills, experience and qualifications employers are looking for. Therefore, knowing how best to transition from your current position to one in human resources will go a long way towards helping you to secure job interviews and more confidently embark on your new career path.

In this guide, we’ll shine a spotlight on the human resources industry, highlighting some of the advantages of transitioning to a role in this field, and revealing ten of the best pathways to make your career change as succ

Up Next

A Beginner’s Guide to Sigmund Freud’s Theory of Dream Interpretation

Sigmund Freud's Theory of Dream Interpretation

Freud is more than the oddball father of psychoanalysis we know him as but has become a cultural phenomenon. Everyone has heard of Freud, from the stranger to psychiatric science to the Master of Mental Health graduate, and with good reason. Before Freud, most psychotherapy simply consisted of getting the mentally ill and psychotic out of the way of “normal” society. This involved shipping them off to asylums where they were largely ignored and left to degenerate. It was Freud’s works and early studies of psychoanalysis that paved the way for the modern therapy and counselling we have today. Among the most famous, was Freud’s contribution to dream analysis, as published in his 1899 work “The Interpretation of Dreams.”